WHO Classification of Acute Myeloid Leukemia

Acute myeloid leukemia with recurrent genetic abnormalities

• Acute myeloid leukemia with t(8;21)(q22;q22), (AML1/ETO)
• Acute myeloid leukemia with abnormal bone marrow eosinophils and inv(16)(p13q22) or t(16;16)(p13;q22), (CBF/MYH11)
• Acute promyelocytic leukemia with t(15;17)(q22;q12), (PML/RAR and variants
• Acute myeloid leukemia with 11q23 (MLL) abnormalities

Acute myeloid leukemia with multilineage dysplasia

• Following MDS or MDS/MPD
• Without antecedent MDS or MDS/MPD, but with dysplasia in at least 50% ofcells in 2 or more myeloid lineages

Acute myeloid leukemia and myelodysplastic syndromes, therapy related

• Alkylating agent/radiation–related type
• Topoisomerase II inhibitor–related type (some may be lymphoid)
• Others

Acute myeloid leukemia, not otherwise categorized
Classify as:

• Acute myeloid leukemia, minimally differentiated
• Acute myeloid leukemia without maturation
• Acute myeloid leukemia with maturation
• Acute myelomonocytic leukemia
• Acute monoblastic/acute monocytic leukemia
• Acute erythroid leukemia (erythroid/myeloid and pure erythroleukemia)
• Acute megakaryoblastic leukemia
• Acute basophilic leukemia
• Acute panmyelosis with myelofibrosis
• Myeloid sarcoma