Complications After HSCT

Early (0-30 Days)
A.Regimen related toxicity
1.Mucositis (65-70%)
2.Myocarditis & Pericarditis from either cyclophosphamide or TBI (rare)
3.Hemorrhagic Cystitis (10%)
4.Veno-occlusive disease (5-40%)
5.Pneumonitis (10- 20%)
6.Alveolar hemorrhage (5-10%)
B.Infections (75%)
C.Graft Failure (2-10%)
D.Adverse drug reactions from Polypharmacy (Common)

Intermediate (1-3 months)
Acute GVHD (20-50%) (more frequent with non-sibling donors)

Late (Beyond 3 months)
A.Chronic GVHD (20 – 40%)
B.Hypothyroidism (30 – 50%)
C.Growth disturbances in children (common)
D.Sterility/Hypogonadysm (common)
E.Cataracts (25 – 40%)
F.Avascular necrosis of bone and demineralization of bone (5 – 15%)
G.Malignant relapse (Variable)
H.Second Malignancy (2-10%)